Cannabidiol (CBD) and cannabidiol acid (CBDA) are two different forms of the cannabis compound. CBD is well-known for its therapeutic benefits, while CBDA has only recently been studied for its potential effects. This article will explore the differences between CBD and CBDA, as well as the potential benefits of each.
Cannabidiol Acid (CBDA)
Definition and Overview
CBDA, or Cannabidiolic Acid, is a naturally-occurring cannabinoid found in the raw form of cannabis plants and hemp. It's structurally similar to CBD but with some key differences that give it unique therapeutic benefits that are still being researched today. Some potential uses include anti-inflammatory and anti-anxiety effects and relief from nausea, vomiting, and convulsions. CBDA can also act as an antiemetic, reducing or preventing nausea caused by chemotherapy treatments.
The Current Research on CBDA
CBDA has been a topic of research for over ten years now. An early 2008 study looked into the potential of CBDA as an anti-inflammatory and found that its molecular structure was similar to common non-steroidal anti-inflammatory drugs (NSAIDs). It was also discovered that CBDA inhibits COX-2 receptors, giving it promise as an effective anti-inflammatory agent.
Similarly, one reason why CBDA is effective against nausea is its affinity for 5-HT receptors, which is 100 times stronger than CBD. Since CBDA has better bioavailability, it's easier for the body to metabolize this compound; thus giving it faster results than other compounds that rely only on CBD.
Perhaps even more promising is its ability to potentially fight depression due to its effects on 5-HT receptors, which are similar to those seen in Selective Serotonin Reuptake Inhibitor (SSRI) medications prescribed by doctors.
Despite the fact that most CBDA studies to date are preclinical, medical cannabis companies such as British-based GW Pharmaceuticals are working to change this. In 2018, their pharmaceutical-grade CBD oil Epidiolex became the first cannabis-derived prescription drug approved by the FDA. The FDA further demanded research on CBDA's precursor be conducted; results showed CBDA to be an even more effective seizure treatment.
GW Pharmaceuticals has also filed two patents related to medical uses of CBDA - one for inflammatory skin diseases and another for cancer treatments. Although the research conducted so far has been limited to isolated cells, initial findings suggest that CBDA may halt the growth of a particularly aggressive form of breast cancer cells known as MDA-MB-231.
10 Potential Benefits
1. Anti-Inflammatory
CBDA may help reduce inflammation and swelling caused by certain medical conditions like arthritis, joint pain, and other inflammatory diseases. Research conducted in cell cultures has demonstrated promising anti-inflammatory properties of CBDa. A 2008 study published in Drug Metabolism and Disposition found that CBDa is a selective COX-2 inhibitor.
The COX-2 enzyme is responsible for producing pro-inflammatory compounds called prostaglandins, which are common targets of non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin. Inflammation is a natural immune response to stress, injury, and illness; however, chronic inflammation can be detrimental to health and result in painful conditions like arthritis.
The research from 2008 found that CBDa selectively blocks the activity of the COX-2 enzyme, diminishing its ability to synthesize pro-inflammatory compounds. This makes CBDa more effective than its counterpart - tetrahydrocannabinolic acid (THCA).
2. Cancer-fighting potential
Some studies indicate that CBDA may be able to fight certain types of cancer. Studies from 2012 have identified the potential for CBDa to hinder migration in breast cancer cells grown outside of the body, indicating a positive effect against an aggressive form of breast cancer. If successful, a therapy that inhibits the migration of cancer cells would be able to prevent its spread to other body parts.
Cell culture research conducted in 2014 further supported these claims, finding that treatment with CBDa could alter gene expression associated with metastasized breast cancer and decrease levels of COX-2, which is known to enhance tumor cell migration.
3. Antiemetic
It can help reduce or prevent nausea caused by chemotherapy treatments and general nausea from other medical conditions. In addition, research conducted on rodents suggests that raw cannabis juice may have the potential as an anti-nausea remedy. A 2012 study published in the British Journal of Pharmacology found that CBDa reduced nausea responses in rodents and suppressed vomiting in shrews; interestingly, CBDa was more effective at calming an upset stomach than activated CBD.
4. Anti-Anxiety
It has been shown to reduce feelings of anxiousness and stress because of its calming effects.
5. Pain relief
CBDA may help reduce pain caused by neuropathy and fibromyalgia.
6. Anti-seizure
Studies suggest that it may reduce the frequency and intensity of seizures.
7. Cardiovascular health
It may help improve cardiovascular health by helping regulate blood pressure and cholesterol levels.
8. Antioxidant activity
CBDA has been shown to contain antioxidant properties which protect against cell damage caused by free radicals in the body.
9. Appetite stimulation
Studies suggest that it may help stimulate appetite in people with trouble eating.
10. Nausea relief
CBDA has been shown to have antiemetic effects, which means it can help relieve nausea or vomiting caused by chemotherapy treatments.
Delivery Methods for Consuming CBDA
CBDA can be ingested orally in the form of capsules or tinctures. You can also apply it on the surface of the skin, and be used topically as a balm or cream and inhaled through vaping.
Considerations when Purchasing CBDA Products
When purchasing any CBDA product, it is vital to ensure that you buy from a reputable source, such as Let it Grow. They are a trustworthy brand because all of their products are third-party tested and have the appropriate labeling to know precisely what you're getting. Additionally, if you plan on using CBDA topically or inhaling it through vaping, research the potential risks of these methods before doing so.
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FAQs about CBDA
Q: Is CBDA more potent than CBD?
Yes, it is believed that CBDA is more potent than CBD as an antioxidant and anti-inflammatory agent.
Q: How can I consume CBDA?
CBDA can be consumed in a variety of ways, including through edibles, tinctures, capsules, and topical applications. However, it is important to remember that there are potential risks associated with some methods, such as vaping.
Q: Is CBDA legal?
The legality of CBDA depends on where you live. In some countries, it is completely legal to purchase and consume, while in others, there are restrictions or even bans on its usage. It is essential to stay updated with your local laws regarding CBD products before making any purchases.
Q: Are there any side effects associated with CBDA?
Some users have reported feeling more relaxed after consuming CBDA, but to date, there are no known serious side effects associated with its use. However, it is always important to consult a medical or health professional before adding new supplements to your routine. Additionally, if you plan on vaping or using topical CBDA, research the potential risks associated with these methods. If you have hesitations, it is best to consult your doctor before use.
Q: What is Decarboxylation?
Decarboxylation is the process of heating CBDA to convert it into CBD, making it possible for the body to absorb and use it. This conversion can be done through a variety of methods, such as smoking or baking it in an oven at a certain temperature.
Cannabidiol (CBD)
CBD, or Cannabidiol, is a naturally-occurring chemical compound that can be extracted from the cannabis plant. It is then processed into an oil form for easier consumption. Unlike its cousin THC (tetrahydrocannabinol), known for its psychoactive properties, CBD does not produce any "high" or intoxication when consumed. Instead, it has been researched to have potential therapeutic benefits in treating certain medical conditions.
Definition and Overview
Cannabidiol (CBD) is a naturally-occurring chemical compound that can be extracted from the cannabis plant. It is then processed into an oil form for easier consumption. Unlike its cousin THC (tetrahydrocannabinol), known for its psychoactive properties, CBD does not produce any "high" or intoxication when consumed. Instead, it has been researched to have potential therapeutic benefits in treating certain medical conditions, such as chronic pain and inflammation, anxiety, and trouble sleeping. In addition to these potential health benefits, CBD is also being explored for its potential anti-inflammatory, anti-anxiety, and analgesic effects.
The Current Research on CBD
Researchers from the University of Chicago have identified that CBD, a product derived from the cannabis plant, may be able to inhibit SARS-CoV-2 infection. Published in Science Advances on January 20th, 2022, the study found that medical records of patients taking an FDA-approved treatment for epilepsy had a significant negative correlation with SARS-CoV-2 positive tests. Clinical trials must be conducted to determine whether specially crafted and highly pure CBD doses can be used to prevent or treat COVID-19; however, this research does not suggest commercially available products with varying potency and quality that can ward off the virus. During the ongoing pandemic, scientists seek new therapies for those infected with coronavirus variants which don't have access to vaccines, especially given the rise of breakthrough infections.
10 Potential Benefits
1. Pain Relief
Studies suggest that CBD may help reduce chronic pain caused by arthritis, fibromyalgia, and other conditions. Animal studies have proposed that CBD could help treat arthritic pain and inflammation. A 2017 study discovered that CBD might be a viable and safe treatment for the joint pain caused by osteoarthritis. Additionally, a 2016 study reported that topical application of CBD has the potential to soothe inflamed arthritis pain. For further proof, a 2014 study found evidence that CBD can be an effective solution for osteoarthritis based on animal models, while a 2011 study observed decreased inflammatory pain in rats through CBD's modulation of how their receptors perceive stimuli.
Inflammation Reduction
It may also help reduce inflammation associated with specific diseases like Crohn's, IBS, and MS.
2. Anxiety relief for better sleep
CBD has been shown to help alleviate symptoms of anxiety and stress. Anxiety can have a negative impact on sleep, leading to issues like poor quality sleep and sleep disorders. Evidence suggests that CBD may be beneficial for treating anxiety-related disorders due to its calming effects on the nervous system. One study revealed that 80% of participants who took CBD for their anxiety experienced decreased anxiety levels within a month. Additionally, over 65% of subjects saw an initial improvement in their sleep after taking CBD, though results varied afterward.
3. Cancer Fighting Potential
Research suggests that CBD may be able to fight certain types of cancer cells as well as inhibit their growth. Moreover, CBD helps people with cancer in different ways. It helps stimulate appetite. Cancer treatment can cause patients to suffer from nausea and a loss of appetite, making it challenging to maintain a healthy weight. While ingesting cannabis products with THC may assist in stimulating the appetite, there is no evidence that CBD can have this type of effect on its own. It helps in relieving pain. CBD affects the CB2 receptors secondarily, potentially leading to a decrease in inflammation that may provide wide-ranging pain relief. THC targets the CB1 receptors and may be useful for managing discomfort resulting from nerve damage.
4. Appetite Stimulation
Studies suggest that it may help stimulate appetite in people suffering from anorexia or other eating disorders. Over the centuries, it has been documented that Cannabis sativa can increase appetite and enhance the flavor and pleasure of food. The actions of cannabinoid molecules in the brain are responsible for these effects, which show the role endocannabinoids can play in appetite control. Recent research in biochemistry and pharmacology supports findings from animal studies that demonstrate a regular role for endocannabinoids in regulating eating behavior. With access to cannabinoid receptor agonists and antagonists, it is possible to create more effective treatments for weight-related disorders. These therapies might be used to limit people's susceptibility to overeating high-calorie foods as well as aid those with decreased appetite or weight loss issues.
5. Help in Epileptic Seizures
In 2018, the FDA approved using CBD as Epidiolex for the treatment of Lennox-Gastaut syndrome and Dravet syndrome seizures in patients aged two and older. Three reputable studies provided evidence for this decision; these included 516 individuals with either form of epilepsy who took either Epidiolex or a placebo alongside other prescribed medicines. The results showed that those taking Epidiolex experienced a decrease in seizure frequency compared to those who were given a placebo.
6. Treat Opioid Addiction
Research from animal and human clinical trials suggests CBD could benefit people dependent on opioids. A study involving individuals with heroin use disorder revealed that after one week of CBD usage, cravings, anxiety, resting heart rate, and salivary cortisol levels had significantly decreased. Additionally, no serious side effects were observed. Additional studies have also found that CBD may help to alleviate symptoms such as anxiety, insomnia, and pain in people suffering from substance use disorders. However, more research is encouraged before any definitive conclusions can be reached.
7. Reduces PTSD Symptoms
In a 2018 study published in the Journal of Alternative and Complementary Medicine, 11 people with PTSD were given CBD as part of their regular psychiatric care in an outpatient setting. Out of the 11 participants, 10 experienced a decrease in symptoms. Margaret Rajnic, a specialist in medical cannabis and CBD, advises combining therapy with any type of cannabis or CBD treatment for PTSD. Moreover, four other human trials from 2012 to 2016 suggest that CBD may be effective for reducing the symptoms associated with PTSD. However, some of those studies included THC, which produces an "entourage effect" when consumed alongside CBD. This entourage effect has been observed to temper the effects of THC while enhancing the potency of CBD.
8. Reduces Diabetic Complications
Tests on human cells showed that CBD might help limit the effects of high glucose levels in other cells, which are often precursors to diabetes and its related complications. This leads researchers to believe that CBD could be advantageous for those who suffer from diabetes and its upstream consequences.
In a separate small study involving 13 people with type 2 diabetes, not on insulin therapy, the participants were given both CBD and a placebo (instead of insulin). Results showed that after taking the CBD, resistin (which increases insulin resistance) decreased. In contrast, glucose-dependent insulinotropic peptide (which is responsible for releasing sufficient amounts of insulin after digestion) increased - compared to prior readings before starting the test. These findings suggest CBD could be a natural remedy for diabetes by helping to regulate hormones related to insulin production.
9. CBD can Fight Covid
Recent research has shown that CBD could help fight Covid-19 by inhibiting the activity of ACE2, an enzyme responsible for allowing the virus to enter cells. This could potentially reduce the severity and duration of symptoms caused by Covid-19.
10. Lessons ALS Symptoms
Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder in which nerve cells in the brain and spinal cord gradually deteriorate, leading to muscular control loss. The underlying cause of ALS remains unknown, although some cases may be hereditary. Unfortunately, there is no known cure for ALS as of yet, and only two FDA-approved medications exist to aid in the management of symptoms.
However, research has shown that people with ALS can often benefit from the entourage effect created when THC and CBD are used together - similar to those with PTSD. A study in 2019 demonstrated the effectiveness of this combination of cannabinoids when administered at various doses depending on the individual's needs and preferences. Those with mild, moderate, or severe spasticity resulting from their ALS found great satisfaction with this treatment; those with moderate to severe spasticity experienced even higher satisfaction than those who had mild spasticity.
Delivery Methods for Consuming CBD
CBD can be ingested orally in capsules, tinctures, or edibles. It can also be vaped, used topically as a cream or balm, and even inhaled through dabbing. Considerations when Purchasing CBD Products When purchasing any CBD product, it is essential to ensure that you buy from a reputable source, such as Let it Grow. You should also make sure that the product is third-party tested and has the appropriate labeling, so you know exactly what you're getting. Additionally, if you plan on vaping or using topical CBD, you should research the potential risks associated with these methods before doing so.
Considerations when Purchasing CBD Products
When purchasing any CBD product, you must ensure that you buy from a reputable source. You should also make sure that the product is third-party tested and has the appropriate labeling, so you know exactly what you're getting. Additionally, if you plan on vaping or using topical CBD, you should research the potential risks associated with these methods before doing so. Finally, different countries have different laws regarding CBD products, so staying up to date with them is important.
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FAQs about CBD
Q: How do I know if a CBD brand is legit or certified? What makes a reputable brand?
When it comes to gauging the quality of a hemp-derived CBD product, it's essential to look at how the source material is treated. The most reliable CBD companies will make their testing Certificates of Analysis (COAs) available to you. They test for potency and purity to confirm that the cannabinoids are beneficial and therapeutic and that there are no dangerous levels of pesticides, toxins, metals, or other harmful chemicals in the product.
Q: How do I know if it is a quality product before purchasing?
Quality CBD products should always be accompanied by a Certificate of Analysis (COA) to verify their purity and potency. Companies should also be transparent about their testing processes and farming protocols.
Full-spectrum CBD contains trace amounts of THC that are within federal legal limits (less than
0.3%). This THC, combined with other cannabinoids, can create the entourage effect – resulting in a more powerful product! Generally, full-spectrum CBD comes with smaller dosages than isolating CBD, which only has CBD and no other key cannabinoids to trigger the entourage effect. With Equilibria's full-spectrum product, members experience noticeable benefits with smaller doses of 20mg - 30mg of CBD per day.
Q: What is the difference between CBD and marijuana?
When discussing cannabis products, "marijuana" refers to THC-containing cannabis with concentrations exceeding the federally permissible amount. Medical dispensaries usually carry various medical-grade items containing higher levels of THC, like tinctures, gummies, chocolates, topicals, and even the flower itself.
CBD products must have a lower federally legal limit of less than
0.3% THC to be available for purchase in all states. Both CBD and THC are molecules from the same plant source, and both can be found in relatively differing quantities depending on the cultivation process.
Q: Can CBD impact a drug test?
Everyone's body reacts differently to different substances, making drug testing difficult. However, it is possible to test positive on a drug test with consistent consumption of full-spectrum CBD products. Think of it like drinking alcohol: the percentage of ABV/Alcohol By Volume present in the drink corresponds to the BAC/Blood Alcohol Level - similarly, the amount of THC present in CBD depends on its concentration (which for our products must be
0.3% or less). The more you consume at a time, the more likely it is to be detected on a test.
If you're worried, pick up an over-the-counter THC test from your local pharmacy. We suggest opting for a blood test rather than urine tests as they tend to be more accurate. Additionally, all our products are federally legal, and customers can furnish their employers with lab results if further questions arise.
Q: Does CBD get you high?
No, CBD does not get you high if it follows the federally legal limit of 0.3%. Generally, the average dose among users is between 20-50mg per day and is not enough to produce a psychotropic effect. If you are sensitive to low levels of THC, it's best to start slowly and increase as needed. Also, remember that trace amounts of THC are included in each product to activate the entourage effect and boost potency. Due to different body chemistries, full-spectrum CBD may affect everyone differently. Therefore, when making any changes or increases to your dosage routine, we recommend trying them on a day at home so you can closely monitor how your body responds and avoid any unexpected results.
Conclusion
In conclusion, CBD has become increasingly popular in recent years as more and more people are discovering its potential health benefits. As with any supplement or medication, it is important to do your research and understand the product before consuming it. Quality CBD products should always come with a Certificate of Analysis (COA) from an independent lab to verify their potency and safety. Additionally, it is important to remember that the FDA does not regulate CBD products, so make sure you only purchase from reputable manufacturers and retailers. Lastly, if you are concerned about drug testing, opt for a product with 0.3% THC or less and check with your employer before consuming any CBD product. Ultimately, full-spectrum CBD is a safe and natural option to explore if you are looking for relief without the psychotropic effects of marijuana. With proper research and understanding, CBD can be an effective choice for health enhancement and symptom management.
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